Brian J Druker Selected Research

BCR-ABL Negative Atypical Chronic Myeloid Leukemia (Leukemia, Myeloid, Philadelphia Negative)

1/2020	Efficacy of Ruxolitinib in Patients With Chronic Neutrophilic Leukemia and Atypical Chronic Myeloid Leukemia.
12/2015	Durable Disease Control with MEK Inhibition in a Patient with NRAS-mutated Atypical Chronic Myeloid Leukemia.
1/2014	Significant clinical response to JAK1/2 inhibition in a patient with CSF3R-T618I-positive atypical chronic myeloid leukemia.

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Brian J Druker Research Topics

Disease

105	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 01/2022 - 01/2002
87	Neoplasms (Cancer) 01/2022 - 01/2002
47	Leukemia 01/2022 - 09/2002
32	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 03/2002
23	Philadelphia Chromosome 01/2021 - 01/2002
16	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 11/2021 - 09/2002
13	Blast Crisis (Blast Phase) 01/2022 - 05/2002
10	Disease Progression 01/2021 - 03/2002
7	Hematologic Neoplasms (Hematological Malignancy) 12/2019 - 04/2006
7	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 03/2015 - 03/2002
5	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 01/2020 - 01/2008
5	Fatigue 01/2010 - 08/2002
4	Chronic Neutrophilic Leukemia 11/2022 - 01/2014
4	Systemic Mastocytosis 03/2006 - 12/2004
3	BCR-ABL Negative Atypical Chronic Myeloid Leukemia (Leukemia, Myeloid, Philadelphia Negative) 01/2020 - 01/2014
3	Primary Myelofibrosis (Myelosclerosis) 02/2016 - 12/2006
3	Hypersensitivity (Allergy) 01/2016 - 01/2013
3	Myeloid Leukemia (Leukemia, Myelocytic) 04/2014 - 01/2003
3	Edema (Dropsy) 05/2012 - 08/2002
3	Genetic Translocation (Chromosomal Translocation) 09/2010 - 06/2002
3	Chromosome Aberrations (Chromosome Abnormalities) 12/2008 - 07/2002
3	Breast Neoplasms (Breast Cancer) 12/2007 - 06/2004
2	Polycythemia Vera 01/2020 - 01/2018
2	Pancreatitis 12/2019 - 11/2012
2	Glioblastoma (Glioblastoma Multiforme) 12/2018 - 11/2013
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2017 - 05/2013
2	Thrombocytosis (Thrombocythemia) 02/2016 - 12/2006
2	Adenocarcinoma of Lung 01/2016 - 11/2013
2	Lung Neoplasms (Lung Cancer) 01/2016 - 11/2013
2	Myeloproliferative Disorders (Myeloproliferative Disorder) 01/2016 - 11/2013
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2015 - 11/2013
2	Carcinogenesis 11/2014 - 06/2012
2	Liver Neoplasms (Liver Cancer) 11/2013 - 06/2004
2	Cholangiocarcinoma 11/2013 - 11/2013
2	Fanconi Anemia (Fanconi's Anemia) 08/2013 - 07/2012
2	Myalgia 05/2012 - 04/2008
2	Exanthema (Rash) 05/2012 - 04/2008
2	Diarrhea 05/2012 - 08/2002
2	Seminoma 01/2006 - 03/2002
2	Cytopenia 07/2002 - 05/2002

Drug/Important Bio-Agent (IBA)

88	Imatinib Mesylate (Gleevec)FDA Link 01/2018 - 01/2002
58	Phosphotransferases (Kinase)IBA 01/2022 - 03/2002
31	Tyrosine Kinase InhibitorsIBA 01/2021 - 03/2002
21	Pharmaceutical PreparationsIBA 01/2022 - 05/2002
18	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2002
17	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021 - 03/2002
14	Dasatinib (BMS 354825)FDA Link 01/2018 - 01/2006
13	bcr-abl Fusion ProteinsIBA 01/2015 - 01/2002
13	Tyrosine (L-Tyrosine)FDA Link 06/2012 - 12/2003
10	ponatinibIBA 01/2020 - 11/2009
8	CytokinesIBA 10/2017 - 10/2006
6	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 11/2020 - 08/2002
6	nilotinib FDA Link 01/2018 - 11/2009
6	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 04/2013 - 05/2003
6	InterferonsIBA 11/2010 - 03/2003
5	venetoclaxIBA 01/2022 - 01/2016
5	Antineoplastic Agents (Antineoplastics)IBA 01/2021 - 10/2006
5	Oncogene Proteins (Oncogene Protein)IBA 01/2019 - 01/2011
4	Protein Isoforms (Isoforms)IBA 01/2015 - 12/2003
4	Cytarabine (Cytosar-U)FDA LinkGeneric 12/2006 - 03/2003
4	Interferon-alpha (Interferon Alfa)IBA 12/2006 - 03/2003
3	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2019 - 03/2015
3	idelalisibIBA 05/2018 - 01/2011
3	LigandsIBA 02/2014 - 03/2002
3	DCC-2036IBA 11/2011 - 01/2011
3	Interleukin-6 (Interleukin 6)IBA 01/2010 - 10/2006
2	Colony-Stimulating Factors (Colony Stimulating Factor)IBA 11/2022 - 01/2014
2	p38 Mitogen-Activated Protein KinasesIBA 01/2022 - 06/2008
2	Messenger RNA (mRNA)IBA 01/2021 - 04/2005
2	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2021 - 08/2013
2	ruxolitinibIBA 01/2020 - 02/2016
2	ibrutinibIBA 01/2020 - 05/2018
2	Lipase (Acid Lipase)FDA Link 12/2019 - 11/2012
2	Adenosine Triphosphate (ATP)IBA 12/2019 - 01/2019
2	RNA (Ribonucleic Acid)IBA 12/2019 - 10/2007
2	Granulocyte Colony-Stimulating Factor (G-CSF)IBA 11/2019 - 02/2014
2	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 11/2018 - 01/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2018 - 11/2006
2	Drug CombinationsIBA 01/2017 - 10/2006
2	CrizotinibIBA 01/2016 - 11/2013
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 12/2015 - 12/2011
2	Anaplastic Lymphoma KinaseIBA 09/2015 - 06/2015
2	Pre-B Cell ReceptorsIBA 03/2015 - 11/2012
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 11/2014 - 09/2008
2	Syk KinaseIBA 02/2014 - 02/2013
2	TOPSIBA 01/2014 - 05/2012
2	tyrosine receptor (receptor, tyrosine)IBA 11/2013 - 04/2013
2	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 08/2013 - 07/2012
2	Amino Acids FDA Link 04/2011 - 02/2009
2	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 06/2008 - 10/2006
2	Epidermal Growth Factor (EGF)IBA 07/2007 - 12/2003
2	tandutinibIBA 12/2006 - 11/2004
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 04/2006 - 06/2004
2	fms-Like Tyrosine Kinase 3IBA 04/2005 - 11/2004
2	Arsenic Trioxide (Trisenox)FDA Link 07/2002 - 04/2002

Therapy/Procedure

79	Therapeutics 01/2022 - 01/2002
5	Drug Therapy (Chemotherapy) 01/2021 - 08/2002
4	Precision Medicine 01/2021 - 12/2015
3	Transplantation 01/2016 - 12/2003
2	Drug Tapering 10/2006 - 07/2002